PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4096)
Related Products (4096)
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PROTAC Linkers Isoform Comparison
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2-(9-Bromononyl)-1,3-dioxolane
0 ImagesCat. No.: HY-W842525CAS No.: 59014-60-7
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MeNH-PEG2-NHMe
0 ImagesCat. No.: HY-W151019CAS No.: 22366-98-9
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(S,R,S)-AHPC-PEG2-NHS ester
0 ImagesCat. No.: HY-W800669CAS No.: 2757045-58-0
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tert-Butyl (trans-3-formylcyclobutyl)carbamate
0 ImagesCat. No.: HY-W056858CAS No.: 171549-92-1
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5-(Methylthio)pentan-1-amine
0 ImagesCat. No.: HY-W841820CAS No.: 55021-78-8
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Azido-PEG1-CH2CO2H (Standard)
0 ImagesCat. No.: HY-108369RCAS No.: 79598-48-4Azido-PEG1-CH2CO2H (Standard) is the analytical standard of Azido-PEG1-CH2CO2H (HY-108369). This product is intended for research and analytical applications. Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H can be used in the synthesis of PROTAC BRD4 Degrader-1. Azido-PEG1-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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3-(3-(3-Ethoxy-3-oxopropoxy)propoxy)propanoicacid
0 ImagesCat. No.: HY-W114669CAS No.: 886362-92-1
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4-Bromo-1,1-dimethoxybutane
0 ImagesCat. No.: HY-W353544CAS No.: 24157-02-6
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Ethyl 6-aminohexanoate
0 ImagesCat. No.: HY-W236654CAS No.: 371-34-6
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N33-TEG-COOH (Standard)
0 ImagesCat. No.: HY-108370RCAS No.: 201467-81-4Synonyms: N3-TEG-COOH (Standard); 14-Azido-3,6,9,12-tetraoxatetradecanoic acid (Standard)N33-TEG-COOH (Standard) is the analytical standard of N33-TEG-COOH (HY-108370). This product is intended for research and analytical applications. N33-TEG-COOH (N3-TEG-COOH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N33-TEG-COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Ph-Bis(C1-N-(C2-NH-Boc)2)
0 ImagesCat. No.: HY-140337CAS No.: 1807521-06-7
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Methyl (4-cyanophenyl)acetate
0 ImagesCat. No.: HY-W005340CAS No.: 52798-01-3
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PEG10-Tos
0 ImagesCat. No.: HY-W906996CAS No.: 1800414-54-3
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Boc-C1-PEG2-C4-Cl (Standard)
0 ImagesCat. No.: HY-108371RCAS No.: 1835705-53-7Synonyms: PROTAC Linker 1 (Standard)Boc-C1-PEG2-C4-Cl (Standard) is the analytical standard of Boc-C1-PEG2-C4-Cl (HY-108371). This product is intended for research and analytical applications. Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
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2-(4-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)piperazin-1-yl)acetic acid dihydrochloride
0 ImagesCat. No.: HY-W338047CAS No.: 204320-65-0
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Pimeloylchloride
0 ImagesCat. No.: HY-W614444CAS No.: 142-79-0
